Systemic Inflammatory Response Syndrome

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  4. Stage 1: Pre-shock Anticipation
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  6. Stage 3: Compensated shock
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  8. Stage 5: Decompensated shock, but irreversible
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Systemic inflammatory response syndrome (SIRS)
is a general inflammatory response to various causes. It is considered to be due to cytokines ("cytokine storm")


SIRS can be diagnosed when two or more of the following are present
(1) Heart rate > 90 beats per minute
(2) Body temperature < 36 or > 38°C
(3) Hyperventilation (high respiratory rate) > 20 breaths per minute or, on blood gas, a PaCO2 less than 32 mm Hg
(4) White blood cell count < 4000 cells/mm3 or > 12000 cells/mm3, or the presence of greater than 10% immature neutrophils.


SIRS + proof of infection = sepsis

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