In severe shock the microcirculation changes dramatically. Those changes are mainly due to a "cytokine storm" induced by extremely severe tissue ischemia or, directly, by a pathogen: (1) the endothelium is activated (vasodilates, becomes pro-coagulant, expresses adhesion molecules), (2) monocytes are activated (and discharge numerous cytokines), (3) white blood cells obstruct some capillaries (4) disseminated intra-vascular coagulation and platelet aggregation plug microcirculation as well.
When there is so much deterioration to the microcirculation, perfusion to organs worsens rapidly....and, as a consequence, systemic shock also worsens extremely rapidly... we are very close to the end, Folks...! ...(cute diagram but bad for the patient...)